Organic letters

Discovery of the chemical function of glycosidases: design, synthesis, and evaluation of mass-differentiated carbohydrate libraries

Y Yu, KS Ko, CJ Zea, NL Pohl

Index: Yu, Yang; Ko, Kwang-Seuk; Zea, Corbin J.; Pohl, Nicola L. Organic Letters, 2004 , vol. 6, # 12 p. 2031 - 2033

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Citation Number: 25

Abstract

Discovery of the catalytic chemical function of the many putative glycosidases coded in genomes currently relies on individual testing of possible substrates, usually as their p- nitrophenol conjugate. Herein, we present an alternative chemical proteomics approach using a synthetic mass-differentiated heat-stable substrate library with mass spectrometry readout. Library components do not serve as reaction inhibitors and both primary and ...

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