Chemistry Letters

1-O-Palmityl-D-glucuronate endows liposomes with long half-life in vivo.

Y Namba, T Sakakibara, M Masada, F Ito, N Oku

Index: Namba, Yukihiro; Sakakibara, Toshiyuki; Masada, Mikio; Ito, Fumiaki; Oku, Naoto Chemistry Letters, 1989 , p. 2145 - 2148

Full Text: HTML

Citation Number: 17

Abstract

More liposomes containing 1-O-palmityl-D-glucuronic acid (PGA), a synthetic glycolipid, bound to macrophages than those containing phosphatidylglycerol did in vitro; however, PGA-liposomes circulated longer in vivo. PGA-liposomes did not aggregate in the presence of serum, but liposomes containing 1-O-palmityl-D-glucose or myristic acid aggregated rapidly, suggesting that both carbohydrate and carboxyl group of PGA are important for ...