Highly Efficient Total Synthesis of the Clostridium??Derived anti??MRSA Antibiotic Closthioamide

F Kloss, T Lincke, C Hertweck

Index: Kloss, Florian; Lincke, Thorger; Hertweck, Christian European Journal of Organic Chemistry, 2011 , # 8 p. 1429 - 1431

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Citation Number: 10

Abstract

Abstract The antibiotic closthioamide from Clostridium cellulolyticum, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient synthetic route. This starts from simple building blocks and involves convergent peptide coupling and polythionation.