Chemical and Pharmaceutical Bulletin

Studies on Carcinostatic Substances. XXXVIII. Chemical and Antitumor Properties of Monofunctional Derivatives of Nitrogen Mustard.

K Sawatari

Index: Sawatari,K. Chemical and Pharmaceutical Bulletin, 1961 , vol. 9, p. 996 - 999

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Abstract

Supported by the fact that N-methyl-N-2-chloroethyl-3-chloropropylamine exhibited a strong antitumor effect on Yoshida sarcoma or series of rat ascites hepatomas, eight derivatives of nitrogen mustard were newly synthesized, which have only one but highly reactive 2- chloroethyl group in a molecule. Antitumor test of these compounds on Yoshida sarcoma was, however, negative.