Ultrasound promoted one pot synthesis of novel fluorescent triazolyl spirocyclic oxindoles using DBU based task specific ionic liquids and their antimicrobial activity

H Singh, J Sindhu, JM Khurana, C Sharma…

Index: Singh, Harjinder; Sindhu, Jayant; Khurana, Jitender M.; Sharma, Chetan; Aneja European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 145 - 154

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Citation Number: 32

Abstract

Abstract Spirocyclic oxindoles and triazolyl derivatives posses remarkable biological activities. In present work, we have described an efficient one pot four-component domino reaction of 1-(prop-2-ynyl) indoline-2, 3-dione, cyclic 1, 3-diketones, malononitrile and various aryl azides in DBU based ionic liquids [DBU-H] OAc and [DBU-Bu] OH under ultrasonic irradiation for the construction of heterocycles, comprising spiro-oxindole, 2- ...