Bactericidal quaternary ammonium salts derived from monochloroacetate esters

…, MY Telegin, EK Skvortsova, TI Maksimova

Index: Epshtein, A. E.; Limanov, V. E.; Telegin, M. Yu.; Skvortsova, E. K.; Maksimova, T. I. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 5 p. 292 - 295 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 5 p. 23 - 26

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Citation Number: 5

Abstract

We esterified higher alcohols with monochloroacetic acid (IV) by heating the components in the presence of concentrated sulfuric acid. Because of the strong activation of the halogen in esters III by the alkoxycarbonyl group alkylation of trimethylamine proceeds readily over several hours at room temperature even in a relatively nonpolar solvent such as benzene.