Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding
T Aya, AD Hamilton
Index: Aya, Toshihiro; Hamilton, Andrew D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2651 - 2654
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Citation Number: 45
Abstract
A family of tetrabiphenylporphyrin-based receptors has been synthesized. Receptor 7 showed sub-nanomolar affinity (Kd= 0.67 nM) in binding to the surface of cytochrome c. In addition, a stoichiometric amount of the receptor 7 caused a lowering in the Tm of cytochrome c from 85 to 35° C.
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