Synthesis of Regioselectively Functionalized Benzo [b] thiophenes by Combined ortho-Lithiation− Halocyclization Strategies

R Sanz, V Guilarte, E Hernando…

Index: Sanz, Roberto; Guilarte, Veronica; Garcia, Nuria Organic and Biomolecular Chemistry, 2010 , vol. 8, # 17 p. 3860 - 3864

Full Text: HTML

Citation Number: 37

Abstract

An efficient synthesis of 3-halo-7-oxygen-functionalized benzo [b] thiophenes bearing different substituents at C-2 has been developed from N, N-diethyl O-3- halophenylcarbamates. The key steps are an ortho-lithiation reaction, which gives rise to 3-

Related Articles:

Regioselective synthesis of 4-and 7-alkoxyindoles from 2, 3-dihalophenols: application to the preparation of indole inhibitors of phospholipase A2

[Sanz, Roberto; Castroviejo, M. Pilar; Guilarte, Veronica; Perez, Antonio; Fananas, Francisco J. Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5113 - 5118]

More Articles...