Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones

…, SW Goldstein, WM Welch, AC Swindell…

Index: Sarges; Goldstein; Welch; Swindell; Siegel; Beyer Journal of Medicinal Chemistry, 1990 ,  vol. 33,  # 7  p. 1859 - 1865

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Citation Number: 31

Abstract

Previous efforts from these laboratories have shown that spiro hydantoins derived from cyclic aromatic ketones have excellent in vitro and in vivo activity as aldose reductase inhibitors, an activity of potential interest in the therapy of chronic complications of diabetes mellitus. 1* 2 We have found earlier (Table V of ref 2) that spiro hydantoin 1 derived from 6- aza-1-tetralone is at least as active as 1-tetralone derivative 2. The finding that 4- ...