Palladium-catalyzed amination of aryl bromides: use of phosphinoether ligands for the efficient coupling of acyclic secondary amines

…, S Wagaw, SL Buchwald

Index: Marcoux, Jean-Francois; Wagaw, Seble; Buchwald, Stephen L. Journal of Organic Chemistry, 1997 , vol. 62, # 6 p. 1568 - 1569

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Citation Number: 202

Abstract

Recent developments in the palladium-catalyzed amination of aryl halides1-7 offer considerable advantages over the classical methods, which require either activated substrates or severe reaction conditions. 8 While these new methods, based on the use of the monophosphine ligand P (o-tolyl) 3 or bis-phosphine ligands BINAP and DPPF, lead to efficient coupling of primary amines and secondary cyclic amines, the arylation of ...