Synthesis and cytotoxic activity of acronycine analogues in the benzo [c] pyrano [3, 2-h] acridin-7-one and naphtho [1, 2-b][1, 7] and [1, 10]-phenanthrolin-7 (14H)-one …
JB Bongui, A Elomri, D Cahard, F Tillequin…
Index: Bongui, Jean-Bernard; Elomri, Abdelhakim; Cahard, Dominique; Tillequin, Francois; Pfeiffer, Bruno; Pierre, Alain; Seguin, Elisabeth Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1540 - 1546
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Citation Number: 23
Abstract
Condensation of 1-bromo-2-naphthalenecarboxylic acid (9) with 7-methoxy-2, 2-dimethyl- 2H-1-benzopyran-5-ylamine (13) followed by acid-mediated cyclization afforded 6-methoxy- 3, 3-dimethyl-3, 14-dihydro-7H-benzo [c] pyrano [3, 2-h] acridin-7-one (15), which was further methylated into 6-methoxy-3, 3, 14-trimethyl-3, 14-dihydro-7H-benzo [c] pyrano [3, 2- h] acridin-7-one (benzo [c] acronycine)(3) and 6, 7-dimethoxy-3, 3-dimethyl-3H-benzo [c] ...
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