Novel pyrazole integrated 1, 3, 4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation

S Ningaiah, UK Bhadraiah, SD Doddaramappa…

Index: Ningaiah, Srikantamurthy; Bhadraiah, Umesha K.; Doddaramappa, Shridevi D.; Keshavamurthy, Shubakara; Javarasetty, Chethan Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 245 - 248

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Citation Number: 21

Abstract

Abstract A novel series of 2-(5-methyl-1, 3-diphenyl-1H-pyrazol-4-yl)-5-phenyl-1, 3, 4- oxadiazoles 7 (a–m) were synthesized either by cyclization of N′-benzoyl-5-methyl-1, 3- diphenyl-1H-pyrazole-4-carbohydrazide 4a using POCl 3 at 120 C or by oxidative cyclization of hydrazones derived from various arylaldehyde and (E)-N′-benzylidene-5- methyl-1, 3-diphenyl-1H-pyrazole-4-carbohydrazide 5 (a–d) using chloramine-T as ...