Synthesis of 4??(pyrazol??5??yl)??1, 2, 4??triazole??3??thiones

CB Vicentini, M Manfrini, AC Veronese…

Index: Vicentini, Chiara B.; Manfrini, Maurizio; Veronese, Augusto C.; Guarneri, Mario Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 1 p. 29 - 32

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Citation Number: 32

Abstract

Abstract Condensation of pyrazolyl isothiocyanates 2 with N-substituted hydrazines provided the 2-methyl/phenyl-4-(pyrazol-5-yl) thiosemicarbazides 3. Cyclization of 3 with formic acid-acetic anhydride or with triethyl orthoacetate-acetic anhydride provided 4- (pyrazol-5-yl)-l, 2, 4-triazole-3-thiones 4a-f and 5-methyl-4-(pyrazol-5-yl)-1, 2, 4-triazole-3- thiones 4g-I respectively.