The discovery and development of a safe, practical synthesis of ABT-869

AW Kruger, MJ Rozema, A Chu-Kung…

Index: Organic Process Research and Development, , vol. 13, # 6 p. 1419 - 1425

Full Text: HTML

Citation Number: 16

Abstract

... This article is part of the Safety of Chemical Processes 09 special issue ... However, a safety evaluation found that the NMP process was not safe for scale-up ... variety of inorganic bases raised the T ONSET for exothermic decomposition to >300 °C. In contrast, organic bases showed ...

Related Articles:

Discovery of N-(4-(3-Amino-1 H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor …

[Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1584 - 1597]

Discovery of N-(4-(3-Amino-1 H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor …

[Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1584 - 1597]

Discovery of N-(4-(3-Amino-1 H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor …

[Journal of Medicinal Chemistry, , vol. 50, # 7 p. 1584 - 1597]

More Articles...