Synthesis of α-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals

CP Sár, É Hideg, I Vass, K Hideg

Index: Sar, Cecilia P.; Hideg, Eva; Vass, Imre; Hideg, Kalman Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 4 p. 379 - 384

Full Text: HTML

Citation Number: 19

Abstract

α-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the α-aryl groups. Introduction of adamantane ring instead of tert-butyl group resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements.