Enantioselective synthesis of (-)-cis-clavicipitic acid

JM Ku, BS Jeong, S Jew, H Park

Index: Ku, Jin-Mo; Jeong, Byeong-Seon; Jew, Sang-Sup; Park, Hyeung-Geun Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 8115 - 8118

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Citation Number: 42

Abstract

An enantioselective synthetic method for (-)-cis-clavicipitic acid (1) was reported. 1 was obtained in 10 steps (99% ee and 20% overall yield) from 1 H-indole-3-carboxylic acid methyl ester (9) via asymmetric phase-transfer catalytic alkylation and diastereoselective Pd (II)-catalyzed intramolecular aminocyclization as key steps.

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