Novel and potent small-molecule urotensin II receptor agonists

…, LK Hansen, R Olsson, U Hacksell, K Luthman

Index: Lehmann, Fredrik; Currier, Erika A.; Clemons, Bryan; Hansen, Lars K.; Olsson, Roger; Hacksell, Uli; Luthman, Kristina Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4657 - 4665

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Citation Number: 7

Abstract

A series of analogs of the non-peptidic urotensin II receptor agonist N-[1-(4-chlorophenyl)-3- (dimethylamino) propyl]-4-phenylbenzamide (FL104) has been synthesized and evaluated pharmacologically. The enantiomers of the two most potent racemic analogues were obtained from the corresponding diastereomeric mandelic amides. In agreement with previously observed SAR, most of the agonist potency resided in the (S) enantiomers. The ...