Structural selectivity of aromatic diamidines

JB Chaires, J Ren, D Hamelberg, A Kumar…

Index: Chaires, Jonathan B.; Ren, Jinsong; Hamelberg, Donald; Kumar, Arvind; Pandya, Vandna; Boykin, David W.; Wilson, W. David Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5729 - 5742

Full Text: HTML

Citation Number: 50

Abstract

Competition dialysis was used to study the interactions of 13 substituted aromatic diamidine compounds with 13 nucleic acid structures and sequences. The results show a striking selectivity of these compounds for the triplex structure poly dA:(poly dT) 2, a novel aspect ...