Synthesis and biological evaluation of pyrido [3′, 2′: 4, 5] furo [3, 2-d] pyrimidine derivatives as novel PI3 kinase p110α inhibitors

M Hayakawa, H Kaizawa, H Moritomo…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2438 - 2442

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Citation Number: 116

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 24 and 25 In screening our chemical library, we identified 2a as another lead compound with structural similarity to 1. Through structural modification of 2a, the novel pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine 10e was identified as a ...