Syntheses of 3-Chloro-7-[(Chlorocarbonyl) Methoxy]-4-Methylcoumarin

…, JG Supko, TL Wolfe, L Malspeis

Index: Phillips, Lawrence R.; Supko, Jeffrey G.; Wolfe, Tracy L.; Malspeis, Louis Synthetic Communications, 1996 , vol. 26, # 9 p. 1805 - 1814

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Abstract

Abstract Two efficient syntheses of 3-chloro-7-[(chlorocarbonyl) methoxy]-4-methylcoumarin are described, one utilizing traditional chemistry starting from 3-chloro-7-hydroxy-4- methylcoumarin, while the other uses a novel reagent, sulfuryl chloride/thionyl chloride, in a one-pot reaction starting from 7-(carboxymethoxy)-4-methylcoumarin.