Helvetica Chimica Acta

Highly Enantioselective Synthesis of Orthogonally Protected (2S)??2, 3??Diaminopropanoates through Catalytic Phase??Transfer Aza??Henry Reaction

G Kumaraswamy, A Pitchaiah

Index: Kumaraswamy, Gullapalli; Pitchaiah, Arigala Helvetica Chimica Acta, 2011 , vol. 94, # 8 p. 1543 - 1550

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Citation Number: 16

Abstract

Abstract The syntheses of enantiomer-enriched orthogonally protected different (2S)-2, 3- diaminopropanoates and unnatural furyl-substituted (tert-butoxy) carbonyl (Boc) as well as (benzyloxy) carbonyl (Cbz) protected amino acid esters are accomplished by means of an enantioselective aza-Henry reaction. A key feature of this protocol is organocatalysis as a genesis of chirality to ensure high enantioselectivity.

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