Synthesis and platelet aggregation inhibitory activity of 4, 5-bis (aryl)-2-substituted-thiazoles

RH Rynbrandt, EE Nishizawa…

Index: Rynbrandt, Ronald H.; Nishizawa, Edward E.; Balogoyen, Doris P.; Mendoza, A. Rene; Annis, Kathleen A. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1507 - 1510

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Citation Number: 23

Abstract

13, R= H 15, R= C1 16, R= OCH, ifications of the original active compound (compound 3) led to many active analogues, one of which (compound 16) is of particular interest. Detailed biological studies of compound 16 will be reported elsewherea8 The preparation of compound 3 is shown in Scheme I. Compound l9 was treated with n-butyllithium, followed by C02, to afford the lithium salt (2). Treatment of 2 with methyliodide in DMF afforded 3. ...