A New General Pathway for Synthesis of Reference Compounds of N-Terminal Valine− Isocyanate Adducts

…, P Rydberg, E Westberg, HV Motwani…

Index: Davies, Ronnie; Rydberg, Per; Westberg, Emelie; Motwani, Hitesh V.; Johnstone, Erik; Toernqvist, Margareta Chemical Research in Toxicology, 2010 , vol. 23, # 3 p. 540 - 546

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Abstract

Adducts to Hb could be used as biomarkers to monitor exposure to isocyanates. Particularly useful is the measurement of carbamoylation of N-terminal valines in Hb, after detachment as hydantoins. The synthesis of references from the reactive isocyanates, especially diisocyanates, has been problematic due to side reactions and polymerization of the isocyanate starting material. A simpler, safer, and more general method for the synthesis ...

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