The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2, 3, 6, 7, 12, 12a-hexahydropyrazino [1', 2': 1, 6] pyrido [3, 4-b] indole-1, 4-dione analogues

A Daugan, P Grondin, C Ruault…

Index: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

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Citation Number: 189

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Racemic compounds bearing structural modifications of the hydantoin ring were prepared from key intermediates 3a,c (cis or trans), as presented in Scheme 1. The hydantoin ...

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