Traceless Tosylhydrazone??Based Triazole Formation: A Metal??Free Alternative to Strain??Promoted Azide–Alkyne Cycloaddition

…, S Brauch, L Gabriel, M Henze, S Stark…

Index: Vanberkel, Sander S.; Brauch, Sebastian; Gabriel, Lars; Henze, Michael; Stark, Sebastian; Vasilev, Dimitar; Wessjohann, Ludger A.; Abbas, Muhammad; Westermann, Bernhard Angewandte Chemie - International Edition, 2012 , vol. 51, # 22 p. 5343 - 5346

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Citation Number: 40

Abstract

The unprecedented impact of the CuI-mediated Huisgen cycloaddition reaction is demonstrated by its manifold applications in the life sciences and material sciences.[1, 2] The requirement of a metal catalyst, however, has limited the utilization of this cycloaddition reaction in areas such as photophysical chemistry and chemical biology. Consequently, several metal-free processes have been developed to serve as orthogonal ligation ...