Unusual amino acids III. Asymmetric synthesis of 3-arylalanines

S Taudien, K Schinkowski, HW Krause

Index: Taudien, Stefan; Schinkowski, Klaus; Krause, Hans-Walter Tetrahedron: Asymmetry, 1993 , vol. 4, # 1 p. 73 - 84

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Citation Number: 29

Abstract

Abstract 21 (Z)-α-N-benzoylamino-β-arylacrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active α-benzoyl-β- arylalanine derivatives with optical yields in the range of 82–95% ee using the cationic rhodium complex of “PROPRAPHOS” as the chiral catalyst. No electronical influences of the substituents at the aryl moiety on the enantioselectivity were observed but a sterical one, ...