Development of 3-phenyl-4, 5, 6, 7-tetrahydro-1H-pyrazolo [4, 3-c] pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors

G Samala, PB Devi, R Nallangi, P Yogeeswari…

Index: Samala, Ganesh; Devi, Parthiban Brindha; Nallangi, Radhika; Yogeeswari, Perumal; Sriram, Dharmarajan European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 356 - 364

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Citation Number: 14

Abstract

Abstract Forty 3-phenyl-4, 5, 6, 7-tetrahydro-1H-pyrazolo [4, 3-c] pyridine derivatives were synthesized from piperidin-4-one by five step synthesis and evaluated for Mycobacterium tuberculosis (MTB) pantothenate synthetase (PS) inhibition study, in vitro activities against MTB, cytotoxicity against RAW 264.7 cell line. Among the compounds, 1-benzoyl-N-(4- nitrophenyl)-3-phenyl-6, 7-dihydro-1H-pyrazolo [4, 3-c] pyridine-5 (4H)-carboxamide (6ac) ...