European Journal of Organic Chemistry

Palladium??Catalyzed Synthesis of Aryl Ketones from Boronic Acids and Carboxylic Acids Activated in situ by Pivalic Anhydride

LJ Gooßen, K Ghosh

Index: Goossen, Lukas J.; Ghosh, Keya European Journal of Organic Chemistry, 2002 , # 19 p. 3254 - 3267

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Citation Number: 78

Abstract

Abstract A new palladium-catalyzed cross-coupling reaction between arylboronic acids and mixed anhydrides, generated in situ from carboxylic acids and pivalic anhydride, is presented. Optimization of the new catalyst and the reaction conditions led to the development of a convenient one-pot ketone synthesis directly from carboxylic and boronic acids in the presence of different (phosphane) palladium complexes in wet THF at 60 C. ...

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