Caffeine Derivatives. 1 III. The Preparation of 8-Methyl-and 8-Ethylcaffeine

RC Huston, WF Allen

Index: Huston; Allen Journal of the American Chemical Society, 1934 , vol. 56, p. 1793

Full Text: HTML

Citation Number: 2

Abstract

The xanthines and isoxanthines differ in that only the latter can be methylated4 directly in the eighth position. According to Biltz and Sauer, lJ3, 9-trimethylisoxanthine is readily methylated in the eighth position with methyl sulfate. This is probably effected by addition of methyl and monomethyl sulfate radicals at the 7-8 double bond, and subsequent elimination of methyl hydrogen sulfate. Apparently the 8-9 double bond in caffeine does not favor the ...