Haloacetylated enol ethers. 8 [12]. Reaction of β??alkoxyvinyl trihalomethyl ketones with guanidine hydrochloride. Synthesis of 4??trihalomethyl??2??aminopyrimidines

N Zanatta, MFM Cortelini, MJS Carpes…

Index: Zanatta, Nilo; Cortelini, Maria De F. M.; Carpes, Marcos J. S.; Bonacorso, Helio G.; Martins, Marcos A. P. Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 509 - 513

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Abstract

Abstract In this work the results of the reaction of β-alkoxyvinyl trihalomethyl ketones 1, 2a-e, with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried out, 4-trihalomethyl-2-amino pyrimidines, β-alkoxyvinyl carboxylic acids, or β-acetal carboxylic esters were obtained.

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