Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications

GN Roviello, D Musumeci, EM Bucci…

Index: Roviello, Giovanni N.; Musumeci, Domenica; Bucci, Enrico M.; Pedone, Carlo International Journal of Pharmaceutics, 2011 , vol. 415, # 1-2 p. 206 - 210

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Abstract

Abstract In this work, we report a technological approach to a novel Fmoc-protected nucleoamino acid, based on l-tyrosine, carrying the DNA nucleobase on the hydroxyl group by means of an ester bond, suitable for the solid-phase synthesis of novel aromatic nucleopeptides of potential interest in biomedicine. After ESI-MS and NMR characterization this building block was used for the assembly of a thymine-functionalized tetrapeptide, ...

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