New Phenylglycine??Derived Primary Amine Organocatalysts for the Preparation of Optically Active Warfarin

TE Kristensen, K Vestli, FK Hansen…

Index: Kristensen, Tor E.; Vestli, Kristian; Hansen, Finn K.; Hansen, Tore European Journal of Organic Chemistry, 2009 , # 30 p. 5185 - 5191

Full Text: HTML

Citation Number: 29

Abstract

Abstract In this work we present new, fully synthetic phenylglycine-derived primary amine organocatalysts useful for the one-step preparation of optically active warfarin, an important anticoagulant. Both enantiomeric forms of the catalysts are equally available and can be prepared by robust procedures without recourse to chromatographic purification. Together with a co-catalyst, particularly acetic acid or 2, 4-dinitrophenol, they can furnish warfarin in ...

Related Articles:

Design and evaluation of inclusion resolutions, based on readily available host compounds

[Mueller, Simona; Afraz, Marcel Cyrus; De Gelder, Rene; Ariaans, Gerry J. A.; Kaptein, Bernard; Broxterman, Quirinus B.; Bruggink, Alle European Journal of Organic Chemistry, 2005 , # 6 p. 1082 - 1096]

Stereoselective Alkylations in Rigid Systems. Effect of Remote Substituents on π-Facial Additions to Lactam Enolates. Stereoelectronic and Steric Effects

[Journal of the American Chemical Society, , vol. 120, # 30 p. 7429 - 7438]

Dicarboximide??based clathrate design. Host synthesis, inclusion formation and x??ray crystal structures of a free host and of inclusion compounds with 2??and 3?? …

[Weber, Edwin; Reutel, Christiane; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L. Journal of Physical Organic Chemistry, 1995 , vol. 8, p. 159 - 170]

Asymmetric Syntheses Vi: Asymmetric Aldol Reaction of D-Camphor Imine Derived From Benzylamine

[Synthetic Communications, , vol. 18, # 11 p. 1291 - 1298]

More Articles...