A practical and efficient synthesis of the selective neuronal acetylcholine-gated ion channel agonist (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl) pyridine maleate (SIB- …

LS Bleicher, NDP Cosford, A Herbaut…

Index: Journal of Organic Chemistry, , vol. 63, # 4 p. 1109 - 1118

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Citation Number: 98

Abstract

... Journal of ... J. Org. Chem. ... While organic amine bases are commonly employed in Sonogashira coupling protocols, there was concern that the presence of triethylamine in a reaction mixture which also contained 8b, a tertiary amine, would complicate the workup and purification. ...

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