Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1, 3-dihydro-2, 1, 3-benzothiadiazole 2, 2-dioxides (WYE-114152)

DJ O'Neill, A Adedoyin, JA Bray…

Index: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6824 - 6831

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Citation Number: 5

Abstract

... Journal of Medicinal Chemistry. ... Chemistry A synthetic route toward the preparation of the 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides is described in Scheme 1. Commercially available (4-benzylmorpholin-2-yl)acetic acid ethyl ester 20 ...