Carboxyl-modified amino acids and peptides as protease inhibitors

SA Thompson, PR Andrews…

Index: Thompson, Stewart A.; Andrews, Peter R.; Hanzlik, Robert P. Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 104 - 111

Full Text: HTML

Citation Number: 96

Abstract

Design Our purpose was to evaluate the inhibitory potential of functional groups incorporated into substrate analogues by testing them against proteases representing several different classes, while at the same time minimizing the amount of swthesis required. To meet this objective we selected five primary target enzymes which were commercially available and well characterized:(1) chymotrypsin (CT), a serine endoprotease preferring ...

Related Articles:

An efficient new procedure for the one-pot conversion of aldehydes into the corresponding nitriles

[Zhu, Jia-Liang; Lee, Fa-Yen; Wu, Jen-Dar; Kuo, Chun-Wei; Shia, Kak-Shan Synlett, 2007 , # 8 p. 1317 - 1319]

Phase transfer catalyzed enantioselective Strecker reactions of α-amido sulfones with cyanohydrins

[Journal of Organic Chemistry, , vol. 71, # 26 p. 9869 - 9872]

Design, Synthesis, Molecular Modeling Studies, and Calpain Inhibitory Activity of Novel α-Ketoamides Incorporating Polar Residues at the P1'-Position

[Journal of Medicinal Chemistry, , vol. 47, # 1 p. 72 - 79]

Design, Synthesis, Molecular Modeling Studies, and Calpain Inhibitory Activity of Novel α-Ketoamides Incorporating Polar Residues at the P1'-Position

[Journal of Medicinal Chemistry, , vol. 47, # 1 p. 72 - 79]

Synthesis of 3, 5-disubstituted 1, 2, 4-oxadiazoles as peptidomimetic building blocks

[Tetrahedron Letters, , vol. 48, # 8 p. 1465 - 1468]

More Articles...