Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile

…, B Rolando, M Giorgis, G Montanaro, E Marini…

Index: Bertinaria, Massimo; Rolando, Barbara; Giorgis, Marta; Montanaro, Gabriele; Marini, Elisabetta; Collino, Massimo; Benetti, Elisa; Daniele, Pier Giuseppe; Fruttero, Roberta; Gasco, Alberto European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 103 - 112

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Citation Number: 3

Abstract

The synthesis, physico-chemical, and biological characterisation of a short series of carnosine amides bearing NO-donor nitrooxy functionalities are described. The NO-donor carnosine analogues and their des-NO derivatives display carnosine-like properties, differing from the lead for their high serum stability. The newly-synthesised compounds are able to complex Cu2+ ions at physiological pH, displaying significant copper ion ...