Chiral synthesis of C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3)

MM Ponpipom, WK Hagmann

Index: Ponpipom, Mitree M.; Hagmann, William K. Tetrahedron, 1999 , vol. 55, # 22 p. 6749 - 6758

Full Text: HTML

Citation Number: 6

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Enantioselective alkylation of chiral amide enolates derived from L-prolinol with β-branched chiral iodides afforded good yields of hydroxy amide adducts, which were elaborated in four steps to give C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3).