Stereoselective synthesis of 2-substituted 6-[1-(2, 6-difluorophenyl) ethyl]-5-methylpyrimidin-4 (3H)-ones

…, MB Navrotskii, AS Eremiichuk, EA Gordeeva

Index: Mai; Artico; Rotili; Novakov; Orlinson; Navrotskii; Eremiichuk; Gordeeva Russian Journal of Organic Chemistry, 2009 , vol. 45, # 10 p. 1531 - 1534

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Abstract

Abstract A procedure has been proposed for the synthesis of 2-(cyclopentylsulfanyl)-6-[(1 R)- 1-(2, 6-difluorophenyl) ethyl]-5-methylpyrimidin-4 (3 H)-one through intermediate (3 R)-4, 4- dimethyl-2-oxotetrahydrofuran-3-yl (2 R)-2-(2, 6-difluorophenyl) propanoate which was obtained from prochiral 2-(2, 6-difluorophenyl) prop-1-en-1-one generated in situ. The proposed procedure may be regarded as stereoselective route to 6-[(1 R)-1-(2, 6- ...