Alkaloids from Alangium j avanicum and Alangium g risolleoides that Mediate Cu2+-Dependent DNA Strand Scission

VC Pham, J Ma, SJ Thomas, Z Xu…

Index: Pham, Van Cuong; Ma, Ji; Thomas, Shannon J.; Xu, Zhidong; Hecht, Sidney M. Journal of Natural Products, 2005 , vol. 68, # 8 p. 1147 - 1152

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Citation Number: 18

Abstract

Crude CH2Cl2-MeOH extracts prepared from Alangium javanicum and A. grisolleoides were found to induce DNA strand breakage in the presence of Cu2+ and were subjected to bioassay-guided fractionation to permit identification of the active principle (s). Javaniside (1), a novel alkaloid possessing an unusual monoterpenoid oxindole skeleton, was identified as an active principle contributing to the DNA cleavage activity observed for the ...