The Stereochemistry of the Hydrogenolysis of 1, 2-Diphenyl-1, 2-propanediol

RA Barnes, BR Juliano

Index: Barnes; Juliano Journal of the American Chemical Society, 1959 , vol. 81, p. 6462,6465

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Citation Number: 11

Abstract

The reductive cleavage of a benzyl group linked to an oxygen, nitrogen or sulfur atom is a rather general reaction that can be effected by hydrogen in the presence of catalysts or by several chemical reducing agents. Previous work on atrolactic acid2 and 2-phenyl-2- butanol3 using a Raney nickel catalyst showed that replacement of the hydroxyl group by hydrogen proceeded predominately with retention of configuration.