Tetrahedron

Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella aff. mirabilis

H Konno, K Nosaka, K Akaji

Index: Konno, Hiroyuki; Nosaka, Kazuto; Akaji, Kenichi Tetrahedron, 2011 , vol. 67, # 47 p. 9067 - 9071

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Citation Number: 5

Abstract

Tokaramide A (1) was isolated by Fusetani et al. from the marine sponge Theonella aff. mirabilis and was shown to highly inhibit cathepsin B with an IC 50 value of 29 ng/mL. 1 Cathepsin B, the most extensively studied enzyme of the group, is not only a lysosomal cysteine protease that plays a role in a large number of physiological processes, but is also known to be involved in various disease stages, such as inflammation, trauma, muscular dystrophy, and tumors. ...