Fluorine in enzyme Chemistry: Part 1. Synthesis of difluoromethylenephosphonate derivatives as phosphate mimics

RD Chambers, R Jaouhari, D O'Hagan

Index: Chambers, R. D.; Jaouhari, R.; O'Hagan, D. Journal of Fluorine Chemistry, 1989 , vol. 44, p. 275 - 284

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Citation Number: 18

Abstract

Abstract Diethyl difluoromethylphosphonylcadmium bromide reacts with allyl and benzyl halides in THF to give the corresponding difluoromethylenephosphonate derivatives. The reaction with allyl bromide affords a versatile synthetic intermediate which undergoes a variety of synthetic transformations and therefore becomes a key compound in the preparation of elaborated difluoromethylenephosphonates of biological significance.