Chinese Chemical Letters

Facile synthesis of a 4-anilinoquinazoline dimer by Suzuki cross-coupling reaction

SP Chen, Y Sun, SB Wan, T Jiang

Index: Chen, Shao Peng; Sun, Yue; Wan, Sheng Biao; Jiang, Tao Chinese Chemical Letters, 2011 , vol. 22, # 9 p. 1033 - 1035

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Citation Number: 2

Abstract

Abstract A novel 4-anilinoquinazoline dimer linked by a carbon–carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by 1 H NMR, 13 C NMR, and HRMS. The inhibition rate of the synthetic 4-anilinoquinazoline dimer 8 against epidermal growth factor receptor-tyrosine kinase enzymes (EGFR) in vitro was 44.4% at the concentration of 5.5 μmol/L.