Hydrophobic cluster formation is necessary for dibenzofuran-based amino acids to function as. beta.-sheet nucleators

KY Tsang, H Diaz, N Graciani…

Index: Tsang, Kwok Yin; Diaz, Humberto; Graciani, Nilsa; Kelly, Jeffery W. Journal of the American Chemical Society, 1994 , vol. 116, # 9 p. 3988 - 4005

Full Text: HTML

Citation Number: 196

Abstract

Abstract: Three dibenzofuran-based amino acid residues, namely 4-(2-aminoethyl)-6- dibenzofuranpropanoic acid (l), 4-(aminomethyl)-6-dibenzofuranethanoic acid (2), and 4- amino-6-dibenzofuranmethanoic acid (3), were prepared in order to compare their physical properties so as to further understand residue 1's ability to nucleate antiparallel@-sheet formation within small peptides in aqueous solution. FT-IR, variable temperature NMR, ...

Related Articles:

Improved Synthesis of the Boc and Fmoc Derivatives of 4-(2'-Aminoethyl)-6-dibenzofuranpropionic Acid: An Unnatural Amino Acid That Nucleates β-Sheet Folding

[Bekele; Nesloney; McWilliams; Zacharias; Chitnumsub; Kelly Journal of Organic Chemistry, 1997 , vol. 62, # 7 p. 2259 - 2262]

The synthesis of dibenzofuran based diacids and amino acids designed to nucleate parallel and antiparallel β-sheet formation.

[Diaz, Humberto; Kelly, Jeffery W. Tetrahedron Letters, 1991 , vol. 32, # 41 p. 5725 - 5728]

More Articles...