Heterogeneous asymmetric addition of diethylzinc to aromatic aldehydes catalyzed by Ti (IV)/imine bridged poly (R)-binaphthol

C Dong, J Zhang, W Zheng, L Zhang, Z Yu…

Index: Dong, Chune; Zhang, Junlong; Zheng, Weizhong; Zhang, Liangfu; Yu, Zuolong; Choi, Michael C.K.; Chan, Albert S.C. Tetrahedron Asymmetry, 2000 , vol. 11, # 12 p. 2449 - 2454

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Citation Number: 39

Abstract

Heterogeneous asymmetric addition of diethylzinc to aldehydes catalyzed by chiral polymer catalysts has been achieved. The conjugated polymers based on a BINOL skeleton were synthesized in five steps and applied to this reaction with yield and ee up to 95 and 84.5%, respectively. These chiral polymers can be easily quantitatively recovered and reused without decreasing of ee or catalytic activity.