Design and synthesis of new fluorinated ligands for the rhodium-catalyzed hydroformylation of alkenes in supercritical CO 2 and fluorous solvents

D Bonafoux, Z Hua, B Wang, I Ojima

Index: Bonafoux, Dominique; Zihao, Hua; Wang, Beihan; Ojima, Iwao Journal of Fluorine Chemistry, 2001 , vol. 112, # 1 p. 101 - 108

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Citation Number: 60

Abstract

Novel fluorous biphenols, 5, 5′-[n-C4F9 (CH2) 3] 2-2, 2′-biphenol and 5, 5′-[n-C4F9 (CH2) 3O] 2-3, 3′-di-tert-butyl-2, 2′-biphenol, as well as enantiopure BINOLs,(S)-6, 6′-[n- C4F9 (CH2) 3] 2-BINOL,(R)-6, 6′-[n-C6F13 (CH2) 3] 2-BINOL, and (S)-6, 6′-[n-C8F17 (CH2) 3] 2-BINOL, are synthesized. These compounds serve as key intermediates for the syntheses of a variety of new fluorous ligands for regioselective and enantioselective ...