Synthesis of 11-deoxyanthracyclinone via (arene) tricarbonylchromium complexes

M Uemura, T Minami, Y Hayashi

Index: Uemura; Minami; Hayashi Journal of the Chemical Society - Series Chemical Communications, 1984 , vol. NO. 17, p. 1193 - 1194

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Citation Number: 22

Abstract

1 I-Deoxydaunomycinone (Ib) has been synthesized via nucleophilic addition to the alicyclic part and directed lithiation at the aromatic part in the (+arene)tricarbonylchromium complexes of the hydronaphthalene derivatives. ... 11-deoxyadriamycin (2a), and 11-deoxycarminomycin (3a), are known to show a significant anticancer activity and less ... Tricarbonyl(v6-styrene)chromium was recognized as being equivalent to a Michael acceptor, in which nucleophilic addition ...