Ti/Ni-Mediated Inter-and Intramolecular Conjugate Addition of Aryl and Alkenyl Halides and Triflates

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Index: Millan, Alba; Alvarez De Cienfuegos, Luis; Miguel, Delia; Campana, Araceli G.; Cuerva, Juan M. Organic Letters, 2012 , vol. 14, # 23 p. 5984 - 5987

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Citation Number: 5

Abstract

In this work, we show that the unique combination of a nickel catalyst and Cp2TiCl allows the direct conjugate addition of aryl and alkenyl iodides, bromides, and to a lesser extent, chlorides and triflates to α, β-unsaturated carbonyls at room temperature, without requiring the previous formation of an organometallic nucleophile. The reaction proceeds inter-and intramolecularly with good functional group compatibility, which is key for the development ...