Synthesis, aerobic cytotoxicity, and radiosensitizing activity of novel 2, 4-dinitrophenylamine tethered 5-fluorouracil and hydroxyurea

…, MR Khoshayand, M Babai, N Adibpour

Index: Khalaj, Ali; Doroudi, Ali Reza; Ostad, Seyed Nasser; Khoshayand, Mohammad Reza; Babai, Mohammad; Adibpour, Neda Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6034 - 6038

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Citation Number: 11

Abstract

Two novel dual functional agents, 3 [3-(2, 4-dinitro-phenylamino)-propyl]-5-fluoro-1H- pyrimidine-2, 4-dione 7 and N-[3-(2, 4-dinitro-phenylamino)-propoxy] urea 8, resulting from linkage of 2, 4-dinitrophenylamine through three carbon atoms with 5-fluorouracil 5 and hydroxyurea 6, respectively, were prepared and their in vitro aerobic cytotoxicities in HT-29 cell line with and without radiation were determined. Compounds 7 and 8 unlike their ...