Mechanistic study of the oxidative degradation of the triazole antifungal agent CS??758 in an amorphous form
E Ueyama, N Suzuki, K Kano
Index: Ueyama, Eiji; Suzuki, Nobuyuki; Kano, Kenji Journal of Pharmaceutical Sciences, 2013 , vol. 102, # 1 p. 104 - 113
Full Text: HTML
Citation Number: 2
Abstract
Abstract In this study, the degradates generated from a pharmaceutical solid were characterized, and a mechanistic pathway underlying their formation was proposed. The chemical stability of a novel triazole antifungal drug, CS-758, deteriorated significantly when the crystal was disordered, and characteristic degradates were generated. A total of eight degradates in solution and nine degradates in a solid state were isolated by preparative ...
Related Articles:
[Konosu, Toshiyuki; Oida, Sadao; Nakamura, Yoshie; Seki, Shinobu; Uchida, Takuya; Somada, Atsushi; Mori, Makoto; Harada, Yoshiko; Kamai, Yasuki; Harasaki, Tamako; Fukuoka, Takashi; Ohya, Satoshi; Yasuda, Hiroshi; Shibayama, Takahiro; Inoue, Shin-Ichi; Nakagawa, Akihiko; Seta, Yasuo Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1647 - 1650]
[Konosu, Toshiyuki; Oida, Sadao; Nakamura, Yoshie; Seki, Shinobu; Uchida, Takuya; Somada, Atsushi; Mori, Makoto; Harada, Yoshiko; Kamai, Yasuki; Harasaki, Tamako; Fukuoka, Takashi; Ohya, Satoshi; Yasuda, Hiroshi; Shibayama, Takahiro; Inoue, Shin-Ichi; Nakagawa, Akihiko; Seta, Yasuo Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1647 - 1650]
[Konosu, Toshiyuki; Oida, Sadao; Nakamura, Yoshie; Seki, Shinobu; Uchida, Takuya; Somada, Atsushi; Mori, Makoto; Harada, Yoshiko; Kamai, Yasuki; Harasaki, Tamako; Fukuoka, Takashi; Ohya, Satoshi; Yasuda, Hiroshi; Shibayama, Takahiro; Inoue, Shin-Ichi; Nakagawa, Akihiko; Seta, Yasuo Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1647 - 1650]